This test can be added on to a previous request as long as there is sufficient sample remaining and the sample is less than 48 hours old. Sample retention by lab: EDTA samples are retained for a minimum of 48 hours at 2-10☌.From: Reference Module in Biomedical Sciences, 2014. (It will also be informative to directly perform an assay (Monoclonal gammopathy evaluation) to identify the M-protein.) Example 2: Patient Bs reported whole blood viscosity is 58 her concurrent (actual) hematocrit. Usually, a given patient's symptoms will reproducibly appear at a given viscosity, although this will vary from patient to patient. Blood viscosity is a further factor that affects PVR, for example when polycythemia increases PVR. If an M-protein is responsible, the plasma viscosity, expressed in cP, will also be increased above the upper limit of normal. Most patients do not become symptomatic until the plasma viscosity exceeds 4.0 cP. Pre analysis storage: do not store, send to laboratory within 4 hours. Test includes directly measured plasma viscosity and the derived whole blood viscosity.children, in the presence of active connective tissue disease or in patients with lymphoma/leukaemia) and subsequently to monitor response to antibiotics.ĬRP samples are analysed in the Chemical Pathology department Sample Requirements It therefore has specific value as an early pointer to bacterial infection where the diagnosis may be difficult (e.g. It tends not to be elevated in viral infections, leukaemia/lymphoma or connective tissue disease. Compared with plasma viscosity it is elevated earlier in infection (6 - 10 hours) and it has a shorter half life (48 hours). is automatable and therefore safer and cheaper to performĬ-Reactive Protein is an acute phase reactant.is technically reproducible and standardised.is stable and relatively small changes are significant for any individual.can be performed on a sample up to 48 hours old.has a lower instance of false normal values.At GHNSHFT the plasma viscosity is used more routinely, and clinicians are advised to use this test in preference to the ESR as the plasma viscosity: Results: Hematocrit and plasma viscosity did. Plasma viscosity and ESR results give very similar information. obesity, hypertension, hyperlipidemia and diabetes, have been evaluated by routine methods. Plasma Viscosity tests are performed at GRH. Their main use is as an objective guide to the underlying activity of certain chronic inflammatory diseases such as temporal arteritis or rheumatoid arthritis. The value of these tests is limited by lack of specificity. infection, neoplasm or inflammatory disease). the increase in assorted plasma proteins and fibrinogen in blood plasma stimulated by a variety of causes (e.g. The Plasma Viscosity, alongside the ESR and C-Reactive Protein tests, gives a measure of the acute phase response i.e.
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